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Real-world effectiveness and safety of 1L polyethylene glycol and ascorbic acid for bowel preparation in patients aged 80 years or older

  • Título: Real-world effectiveness and safety of 1L polyethylene glycol and ascorbic acid for bowel preparation in patients aged 80 years or older
  • Autores: Machlab, S; Lorenzo-Zúñiga, V; Pantaleon, MA; Sábado, F; Arieira, C; Arellano, EP; Cotter, J; Carral, DC; Disla, CT; Gorjao, R; Esteban, JM; Rodriguez, S
  • Revista: Endosc Int Open
  • IF: 2,3
  • Quartil: Q2
  • DOI: 10.1055/a-2525-9938
  • Centro: Hospital Universitario La Zarzuela
  • Departamento/servicio: Aparato Digestivo

Abstract:

Background and study aims Clinical trials and real-world studies show a 1L polyethene glycol and ascorbic acid solution (1L PEG-ASC) to be an effective and safe bowel preparation for colonoscopy in the general population. Here, the effectiveness and safety of 1L PEG-ASC were evaluated in patients aged 80 years or older in a real-world setting. Patients and methods A post-hoc analysis of an observational, multicenter, retrospective study assessed the effectiveness and safety of 1L PEG-ASC on outpatients aged >= 80 years old undergoing colonoscopy at eight centers in Spain and Portugal. Cleansing quality was assessed using the Boston Bowel Preparation Scale, with overall scores >= 6 and all segmental scores >= 2 considered adequate colon cleansing, and overall scores >= 8 or 3 in the right colon considered high-quality cleansing. Cecal intubation rate, withdrawal time, polyp and adenoma detection rates (ADR), and adverse events (AEs) were also monitored. Results Data were analyzed from 423 patients aged >= 80 years; mean age 83.5 years (+/- 3.2) and 49.2% males. The adequate colon cleansing success rate was 88.9%, with high-quality cleansing of the overall and right colon achieved in 54.1% and 46.1% of patients, respectively. Colonoscopy was complete in 94.1% of cases and the ADR was 51.3%. At least one AE was experienced by 4.5% of participants, the most frequent being mild dehydration (2.8%) and nausea (1.2%). Conclusions This post-hoc analysis confirms 1L PEG-ASC to be an effective and safe bowel cleansing preparation for patients aged 80 years or older in a real-world setting. (Summary); Machlab, S (corresponding author), Parc Tauli Hosp Univ, Inst Invest & Innovacio Parc Tauli I3PT, Gastroenterol, Sabadell, Spain. (Author of contact)

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